ORIGINAL ARTICLE  
Efficacy of Local Anesthesia during External  
Dacryocystorhinostomy with 1:200,000 Adrenaline  
Versus 1:50,000 Adrenaline  
Muhammad Sharjeel1, Mehr-un-Nisa2, Usama Iqbal3, Rafay Razzaq Wattoo4  
1Gomal Medical College, Dera Ismail Khan, 2,3Department of Ophthalmology, DHQ-UTH, Gujranwala  
4Department of Ophthalmology, Lakson Medical Trust, Sahiwal  
ABSTRACT  
Purpose: To compare the efficacy of local anesthesia during Dacryocystorhinostomy using xylocaine with  
1:200,000 adrenaline versus with 1:50,000 adrenaline.  
Study Design: Quasi experimental study.  
Place and Duration of Study: DHQ Hospital, Dera Ismail Khan, from January to December 2019.  
Material and Methods: We compared two different formulations of local anesthesia during  
Dacryocystorhinostomy in terms of efficacy of per-operative pain, bleeding and effectiveness of anesthesia. 50  
patients fulfilling our inclusion criteria were divided in two groups each containing 25 patients. In group A patients  
underwent Dacryocystorhinostomy under local anesthesia using Bupivacaine and the commercially available  
xylocaine with 1:200,000 adrenaline while patients in the group B underwent surgery using Bupivacaine,  
Xylocaine with 1:50,000 adrenaline. Per-operative pain, bleeding and effectiveness of anesthesia were measured  
on a numeric scale. Means of pain score, bleeding score and anesthesia effectiveness score were computed and  
were compared.  
Results: In group A, 84% patients were females and 16% were male. In group B, 80% were females and 20%  
were males. Mean age of patients was 41.04 ± 6.84 and 40.80 ± 8.563 years in group A and B respectively. Mean  
pain score in group A was 2.20 while in group B was 1.72. Mean bleeding score in Group A was 1.84 while in  
group B was 1.24. Mean Anesthesia effectiveness score in group A was 2.08 while in group B was 2.76.  
Conclusion: Local anesthesia with concentrated adrenaline (in patients with no cardiac disease or other major  
co-morbidity) provides a better control of per-operative pain, bleeding and better anesthesia.  
Key Words: Dacryocystorhinostomy, Epiphora, Xylocaine, Bupivacaine, Anesthesia, Nasolacrimal duct  
obstruction, Adrenaline, Epinephrine.  
How to Cite this Article: Sharjeel M, Nisa Mu, Iqbal U, Wattoo RR. Comparison of Efficacy of Local Anesthesia  
during External Dacryocystorhinostomy with 1:200,000 Adrenaline Versus 1:50,000 Adrenaline. Pak J  
Ophthalmol. 2020; 36 (3): 287-291.  
Doi: 10.36351/pjo.v36i3.1032  
presenting to the ophthalmology department, and one  
of the most common reasons for referral to the  
INTRODUCTION  
Epiphora is one of the most common complaints  
oculoplastic units. Persistent epiphora can be attributed  
____________________________________________  
to reflex tearing or poor tear outflow. The latter can be  
associated with naso-lacrimal duct obstruction  
(NLDO) which can be congenital, acquired or  
idiopathic1. Treatment of epiphora due to congenital  
NLDO is therapeutic lacrimal probing if spontaneous  
resolution does not occur beyond nine month of age2.  
Correspondence to: Usama Iqbal  
DHQ-UTH, Gujranwala  
Email: usamaiqbal@gmail.com  
Received: March 31, 2020  
Accepted: Mat 4, 2020  
Revised: April 23, 2020  
Pakistan Journal of Ophthalmology, 2020, Vol. 36 (3): 287-291  
287  
Muhammad Sharjeel, et al  
Unlike congenital nasolacrimal duct obstruction in  
which lacrimal probing and syringing has a high  
success rate, acquired nasolacrimal duct obstruction in  
adults gets minimal benefit from probing and  
syringing in terms of treatment3. Most of the patients  
need surgical intervention to overcome the  
obstruction4.  
acute infection, having history of previous DCR and  
those not willing to participate in the study or refusing  
surgery under local anesthesia were excluded from our  
study. All the patients were adults from 18-60 years  
old. Patients participating in our study were divided in  
two groups. First 25 patients booked for DCR surgery  
were allocated to group A, next 25 patients during  
study period were allotted to group B.  
External Dacryocystorhinostomy (DCR) was  
introduced in 1904 by a French Ophthalmologist,  
AdeoToti5. Since then different ophthalmologists have  
developed various techniques for this procedure.  
External DCR remains the most commonly performed  
surgery for this purpose and is considered a gold  
standard technique6. Success rate of external DCR is  
upto 91% as compared to 63 – 75% for endonasal  
DCR7.  
All the patients had complete ophthalmic  
examination before surgery. General physical health of  
the patients was also assessed in terms of hypertension  
and diabetes. Those having uncontrolled hypertension  
and poor glycemic control were excluded from our  
study.  
Patients in group A underwent DCR under local  
anesthesia i.e. 5 ml anesthetic formulation made by 2.5  
ml of 2% Bupivacaine and 2.5 ml of commercially  
available 2% xylocaine, with 1:200,000 adrenaline  
(0.005 mg/ml); whereas those in group B had their  
surgery done under local anesthesia with 2.5 ml of 2%  
Bupivacaine, 2.4 ml of 2% Xylocaine and 0.1 ml of  
1:50,000 adrenaline (0.02 mg/ml). Injection of local  
anesthetic was given at three points; Supratrochlear  
block, infra-trochlear block and 10 mm from medical  
canthus. No sedative or Intra muscular analgesics were  
used in any case.  
External DCR is not performed routinely in  
private sector hospitals. This procedure is mostly  
performed in public sector hospitals. To deal with  
large number of patients with complaint of epiphora  
presenting to public sector hospitals, it is often  
required to perform this procedure in local anesthesia  
(LA). There are certain drawbacks of performing this  
procedure in LA8. The most problematic per-operative  
complication during external DCR is bleeding from  
the highly vascular nasolacrimal apparatus, which  
prolongs the surgical time and reduces patient comfort.  
Another troublesome complication during the surgery  
is ineffective analgesia. To overcome these  
complications various techniques have been employed  
like use of a vasoconstrictive agents e.g. adrenaline,  
raising the head end of the table, good nasal packing or  
using cautery9. Use of adrenaline along with the local  
anesthetic has beneficial effects in terms of reduced  
per-operative bleeding and more concentration of the  
local anesthetic at the place of interest10.  
Except for the concentration and formulation of  
local anesthesia, there was no difference in the surgical  
technique in both groups and all surgeries were  
performed by the same surgeon. Per-operative pain,  
bleeding and effectiveness of anesthesia were noted in  
both the groups and were compared. Scoring of Pain,  
bleeding and anesthesia effectiveness was done using  
the scoring table shown below (table 1). Pain was  
assessed on a numeric scale by asking the patient  
during the procedure and postoperatively. Per-  
operative bleeding was scored on the basis of number  
of gauze packs (one gauze pack contain 10 gauze  
pieces) used during procedure. Effectiveness of  
anesthesia was measured in terms of number of doses  
required during the surgery. Data was recorded in  
excel spreadsheets and analyzed using SPSS version  
20. Descriptive statistics were used to describe the  
data. Means of pain score, bleeding score and  
anesthesia effectiveness score for both groups were  
compared.  
In this study we intend to compare two different  
concentrations of adrenaline used along with local  
anesthetic, in terms of their beneficial outcomes in the  
form of reduced pain, per-operative bleeding and  
effectiveness of anesthesia.  
MATERIAL AND METHODS  
This study started after approval from the ethical  
committee of DHQ Hospital Dera Ismail Khan. 50  
patients presenting to the outpatient ophthalmology  
department who were diagnosed as cases of primary  
nasolacrimal duct obstruction were selected. Patients  
suffering from any kind of cardiovascular disease,  
RESULTS  
In group A, 21 (84%) patients were females and 4  
(16%) were males. In group B 20 (80%) patients were  
288  
Pakistan Journal of Ophthalmology, 2020, Vol. 36 (3): 287-291  
Efficacy of Local Anesthesia during External Dacryocystorhinostomy with 1:200,000 Adrenaline Versus 1:50,000 Adrenaline  
Table 1: Scoring of pain, bleeding and effectiveness of  
females and 5(20%) were males. Mean age of patients  
in group A was 41.04 ± 6.84 years and in group B was  
40.80 ± 8.563 years.  
anesthesia.  
Grade of pain  
Score  
Epiphora with discharge was the chief presenting  
complaint in the patients of both the groups.  
Regurgitation test was positive in all the patients of  
both the groups. Intra operative complications were  
failure to suture nasal mucosa and lacrimal sac flaps in  
one patient of group A because of damage to lacrimal  
mucosa during osteotomy. Most common post-  
operative finding was periorbital swelling followed by  
No pain  
Mild pain  
0
1
2
3
Moderate pain ( controllable)  
Severe pain (un- controllable)  
Bleeding  
Minimal ( 2 gauze packs used)  
Moderate (2-5 gauze packs used)  
Massive (more than 5 gauze packs used)  
Effectiveness of anesthesia  
No additional dose required  
Control with 1 additional dose  
Control with >1 additional dose  
Score  
1
2
3
Score  
3
2
1
Table 2: Pain, bleeding and anesthesia in group A and B.  
Group A  
Group B  
N
Min  
Max  
Mean  
2.20  
1.84  
Std. Dev  
.500  
.473  
Min  
Max  
Mean  
1.72  
1.24  
Std. Dev  
.542  
.436  
Pain  
Bleeding  
Anesthesia Effect  
25  
25  
25  
1
1
1
3
3
3
1
1
2
3
2
3
2.08  
.640  
2.76  
.436  
patients, it is often required to perform this procedure  
in local anesthesia (LA).  
3
2.76  
2.2  
Xylocaine 1%–2% without and with adrenaline  
(1:100,000 or 1:200,000) is available commercially. It  
is the local anesthetic most commonly used for  
surgical procedures11. Addition of adrenaline decreases  
systemic absorption and also provides good anesthesia  
and better control of bleeding11. Xylocaine is mostly  
given in a preparation combined with Bupivacaine,  
which is a long acting local anesthetic12.  
2.08  
1.84  
2
1
0
1.72  
1.24  
Pain  
Bleeding  
Group A Group B  
Anesthesia  
It has been observed by Shoroghi et al. that  
increasing the concentration of adrenaline during  
dermatologic surgery reduces the surgical time and  
also reduces the per-operative bleeding13. Adrenaline  
in a concentration of 10µg/mL (1:100,000) in the local  
anesthetic is under use for different oculoplastic  
procedures14. There is no enough evidence available  
on its use in a concentration of 20 µg/mL (1:50,000) in  
ophthalmic surgery.  
Fig. 1: Difference in pain, bleeding and anesthesia between group  
A and B.  
ecchymosis. Descriptive statistics of pain, bleeding  
and effectiveness of anesthesia scores of the group A  
and B are shown in table 2.  
Adrenaline in a concentration of 20 µg/mL  
(1:50,000) is used for many day care dental  
procedures. The maximum recommended dose (MRD)  
of adrenaline in LA formulations for healthy adults is  
0.2 mg per visit15. Based on this recommendation, the  
maximum safe dose of Xylocaine in mL with  
adrenaline 20µg/mL (1:50,000), is 10 mL16. In our  
study 6 patients (n = 25) in group B received 10 mL of  
DISCUSSION  
External DCR is the gold standard procedure for NLD  
blockage in adults. This procedureis not performed  
routinely in private sector hospitals. Because of this  
reason there is increase burden of NLD blockage  
patients presenting to public sector hospitals. Because  
of long surgical booking time and increased burden of  
Pakistan Journal of Ophthalmology, 2020, Vol. 36 (3): 287-291  
289  
Muhammad Sharjeel, et al  
xylocaine w/adrenaline 20 µg/mL (1:50,000). No  
patient required more than 1 dose of local anesthetic.  
Dr. Muhammad Sharjeel; Senior Registrar: Data  
collection, manuscript review.  
Dr. Mehr-un-Nisa; Postgraduate Trainee: Manuscript  
writing and review.  
It is important to mention that adrenaline has a  
relatively narrow therapeutic window17. Adverse  
effects which can occur include restlessness, agitation,  
anxiety, tremulousness, headache, dizziness, pallor,  
palpitation, and tachycardia. These side effects have  
been reported even with the administration of  
recommended therapeutic doses18. In our study no  
major side effects were noted. Complaint of headache  
and tachycardia was noted in a few patients, but it was  
attributed to be post-surgical effect.  
Dr. Usama Iqbal; Postgraduate Trainee: Manuscript  
writing, Data analysis, Data entry.  
Dr  
Rafay  
Razzaq  
Wattoo;  
Consultant  
Ophthalmologist: Manuscript writing, Literature  
review, final review.  
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Ethical Approval  
The study was approved by the Institutional review  
board/Ethical review board.  
Conflict of Interest  
Authors declared no conflict of interest.  
Authors’ Designation and Contribution  
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